The combination of pembrolizumab (Keytruda), and lenvatinib (Lenvima) demonstrated promising clinical activity with no unexpected toxicities in patients with malignant pleural mesothelioma (MPM), according to results from the PEMMELA study (NCT04287829) presented at the International Association for the Study of Lung Cancer 2022 World … [Read more...]
Gallbladder Side Effects Related to Byetta and Other GLP-1 Receptor Agonists
Cases of gallbladder side effects related to Byetta, Trulicity, Ozempic, and Adlyxin were reported in this August 2022 medical journal JAMA Internal Medicine article, “Acute cholecystitis associated with the use of glucagon-like peptide-1 receptor agonists reported to the US Food and Drug Administration”, which starts with the following: The … [Read more...]
The silent malignant mesothelioma epidemic: a call to action
Malignant mesothelioma, recognised as a new disease in the 1950s, is almost exclusively caused by asbestos exposure and usually diagnosed decades after first exposure. The disease was initially restricted to asbestos workers, but diagnoses after non-occupational [ asbestos exposure ] continue to surge. Despite the acknowledgment by WHO and the … [Read more...]
Camp Lejeune Claims for Veterans and Family Diagnosed With Cancers
The Camp Lejeune Justice Act of 2022 allows for claims to be filed against the US Government seeking legal compensation for veterans and their family members who have been diagnosed with serious medical conditions, diseases, and cancers that are associated with harmful chemicals that were in the Camp Lejeune contaminated water they used during 1953 … [Read more...]
Breast Implants Lymphoma Cancer ALCL Case Numbers Increasing Rapidly in the US
There is some new medical research about current population-based estimates of the incidence of breast implants-associated anaplastic large cell lymphoma (BIA-ALCL) -- more commonly called breast implants lymphoma cancer -- in the US, and the findings are rather alarming. From this recent news report, "ALCL Increasing Rapidly in US Women as … [Read more...]
Galinpepimut-S Plus Nivolumab Extends Survival in Malignant Pleural Mesothelioma
The combination of galinpepimut-S and nivolumab (Opdivo) was found to extend survival in patients with malignant pleural mesothelioma who were either refractory to, or who had relapsed after, at least 1 line of standard therapy, according to updated data from a phase 1 trial (NCT04040231). The median overall survival (OS), which was calculated … [Read more...]
Second Surgery for Recurrent Malignant Pleural Mesothelioma after Multimodality Treatment: A Systematic Review
Malignant pleural mesothelioma (MPM) is an aggressive asbestos-related tumour with poor prognosis. To date, a multimodality treatment, including chemotherapy and surgery, with or without radiotherapy, is the gold standard therapy for selected patients with epithelioid and early-stage MPM. In this setting, the goal of surgery is to achieve the … [Read more...]
Copiktra May Increase Risks of Death and Serious Side Effects
From this June 30, 2022, FDA Drug Safety Communication, “FDA warns about possible increased risk of death and serious side effects with cancer drug Copiktra (duvelisib)”, we get the following: To evaluate the long-term safety of Copiktra, we required the drug manufacturer, Secura Bio, to submit the final 5-year survival results from the clinical … [Read more...]
A Case Report of Hypophosphatemia Leading to the Diagnosis of Mesothelioma
Hypophosphatemia can be commonly encountered as an electrolyte imbalance and is defined as a value less than 0.8 mmol/l (2.5 mg/dl). It can be an incidental finding, but it is not uncommon to see it presenting with varied symptoms. It is good to have a clear diagnostic approach to this so adequate treatment can be instated. We present a … [Read more...]
Xalkori Side Effects: Children Suffering Ocular Toxicity and Severe Visual Loss
A June 14, 2022, European Pharmaceutical Review (EPR) article about the most recent meeting of EMA’s Pharmacovigilance Risk Assessment Committee (PRAC) reports a new drug safety issue involving Xalkori and vision loss found in clinical trials for pediatric patients treated with Xalkori. In relevant part from this EPR article about the EMA’s PRAC … [Read more...]
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