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Preoperative immunotherapy for mesothelioma shows favorable outcomes

December 16, 2022 By Law Offices of Thomas J. Lamb, P.A.

In a study published recently in the journal Clinical Cancer Research, researchers at Baylor College of Medicine found that treating patients who have resectable malignant pleural mesothelioma, meaning that their tumor can be removed with surgery, with immunotherapy [ with immune checkpoint inhibitors ] ahead of surgery resulted in favorable … [Read more...]

Filed Under: Mesothelioma Tagged With: mesothelioma, mesothelioma treatments, pleural mesothelioma

Pembrolizumab / Lenvatinib Combo Shows Positive Clinical Activity in Recurrent Pleural Mesothelioma

September 16, 2022 By Law Offices of Thomas J. Lamb, P.A.

The combination of pembrolizumab (Keytruda), and lenvatinib (Lenvima) demonstrated promising clinical activity with no unexpected toxicities in patients with malignant pleural mesothelioma (MPM), according to results from the PEMMELA study (NCT04287829) presented at the International Association for the Study of Lung Cancer 2022 World … [Read more...]

Filed Under: Mesothelioma Tagged With: Keytruda, Lenvima, malignant pleural mesothelioma (MPM), mesothelioma, mesothelioma treatments

Galinpepimut-S Plus Nivolumab Extends Survival in Malignant Pleural Mesothelioma

August 8, 2022 By Law Offices of Thomas J. Lamb, P.A.

The combination of galinpepimut-S and nivolumab (Opdivo) was found to extend survival in patients with malignant pleural mesothelioma who were either refractory to, or who had relapsed after, at least 1 line of standard therapy, according to updated data from a phase 1 trial (NCT04040231). The median overall survival (OS), which was calculated … [Read more...]

Filed Under: Mesothelioma Tagged With: malignant pleural mesothelioma (MPM), mesothelioma, mesothelioma treatments

Second Surgery for Recurrent Malignant Pleural Mesothelioma after Multimodality Treatment: A Systematic Review

July 11, 2022 By Law Offices of Thomas J. Lamb, P.A.

Malignant pleural mesothelioma (MPM) is an aggressive asbestos-related tumour with poor prognosis. To date, a multimodality treatment, including chemotherapy and surgery, with or without radiotherapy, is the gold standard therapy for selected patients with epithelioid and early-stage MPM. In this setting, the goal of surgery is to achieve the … [Read more...]

Filed Under: Mesothelioma Tagged With: malignant pleural mesothelioma (MPM), mesothelioma, mesothelioma treatments

Clinical-pathological characteristics and prognostic factors for malignant peritoneal mesothelioma in the elderly

June 23, 2022 By Law Offices of Thomas J. Lamb, P.A.

Background:  Malignant peritoneal mesothelioma (MPM) is a rare disease characterized by atypical symptoms, difficult diagnosis, variable course and poor prognosis, and it develops mainly in elderly individuals. The authors aimed to identify the clinical-pathological characteristics, prognosis, and prognostic factors in elderly [ malignant … [Read more...]

Filed Under: Mesothelioma Tagged With: mesothelioma, mesothelioma treatments, peritoneal mesothelioma

Early Clinical Activity With CDK4/6 Inhibitor in Pretreated Mesothelioma

March 14, 2022 By Law Offices of Thomas J. Lamb, P.A.

[ Verzenio (abemaciclib), a drug that has proven effective in breast cancer, ] showed preliminary activity in its first-ever clinical trial in mesothelioma. The cyclin-dependent kinase (CDK) 4/6 inhibitor [ Verzenio (abemaciclib) ] achieved disease control at 12 weeks in 14 of 26 patients with progressive mesothelioma associated with a CDKN2A … [Read more...]

Filed Under: Mesothelioma Tagged With: mesothelioma, mesothelioma treatments

First-line nivolumab plus ipilimumab versus chemotherapy in patients with unresectable malignant pleural mesothelioma: 3-year outcomes from CheckMate 743

February 22, 2022 By Law Offices of Thomas J. Lamb, P.A.

Background: In the phase 3 CheckMate 743 study (NCT02899299), first-line nivolumab plus ipilimumab significantly improved overall survival (OS) versus chemotherapy in patients with unresectable malignant pleural mesothelioma [(unresectable MPM)]. We report updated data with 3-year minimum follow-up. Patients and methods: Adults with previously … [Read more...]

Filed Under: Mesothelioma Tagged With: ipilimumab, malignant pleural mesothelioma (MPM), mesothelioma, mesothelioma treatments, nivolumab

Incidence, treatment and survival of malignant pleural and peritoneal mesothelioma: a population-based study

February 15, 2022 By Law Offices of Thomas J. Lamb, P.A.

Introduction:  Malignant mesothelioma (MM) is an aggressive cancer that primarily arises from the pleura (MPM) or peritoneum (MPeM), mostly due to asbestos exposure. This study reviewed the Dutch population-based incidence, treatment and survival since the national ban on asbestos in 1993. Materials and methods:  Patients with MPM or MPeM … [Read more...]

Filed Under: Asbestos, Mesothelioma Tagged With: malignant pleural mesothelioma (MPM), mesothelioma, mesothelioma diagnosis, mesothelioma treatments, peritoneal mesothelioma

Malignant pleural mesothelioma patients’ experience by gender: findings from a cross-sectional UK-national questionnaire

February 2, 2022 By Law Offices of Thomas J. Lamb, P.A.

OBJECTIVES: Malignant mesothelioma is an aggressive malignancy of mesothelial surfaces, most commonly those of the pleura. The aim of this study was to understand, using a national questionnaire, the gendered care experiences of patients with malignant pleural mesothelioma (MPM). Patients were asked about their experience of the diagnostic process, … [Read more...]

Filed Under: Mesothelioma Tagged With: malignant pleural mesothelioma (MPM), mesothelioma, mesothelioma diagnosis, mesothelioma treatments

Surgical Risk and Survival Associated With Less Invasive Surgery for Malignant Pleural Mesothelioma

January 13, 2022 By Law Offices of Thomas J. Lamb, P.A.

We compared less invasive surgery with conventional surgery for malignant pleural mesothelioma (MPM). We retrospectively reviewed consecutive patients with MPM who received surgery at Hyogo College of Medicine between July 2004 and April 2016. Patients underwent multimodal treatment comprising chemotherapy (neoadjuvant and/or adjuvant) and surgery … [Read more...]

Filed Under: Mesothelioma Tagged With: malignant pleural mesothelioma (MPM), mesothelioma, mesothelioma treatments, pneumonectomy

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