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Malignant Pleural Mesothelioma Clinical Practice Guidelines (SEOM, 2021)

March 4, 2021 By Law Offices of Thomas J. Lamb, P.A.

Diagnosis and Staging:  Genomic studies are not recommended in routine clinical practice but may be appropriate in selected patients with malignant pleural mesothelioma (MPM), especially those with young age and family history of cancer, who may carry germline mutations in cancer susceptibility genes. Chest computed tomography (CT) scan … [Read more...]

Filed Under: Mesothelioma Tagged With: malignant pleural mesothelioma (MPM), mesothelioma, mesothelioma diagnosis, mesothelioma treatments

Questioning the prognostic role of BAP-1 immunohistochemistry in malignant pleural mesothelioma: A single center experience with systematic review and meta-analysis

July 17, 2020 By Law Offices of Thomas J. Lamb, P.A.

Introduction:  The prognostic role of BRCA1 associated protein-1 (BAP1) expression in malignant pleural mesothelioma (MPM) is a matter of debate. We aimed to clarify whether [ malignant pleural mesothelioma patients ] with loss of BAP1 expression have better overall survival (OS) compared to BAP1 positive patients. Methods:  [ BRCA1 … [Read more...]

Filed Under: Mesothelioma Tagged With: malignant pleural mesothelioma (MPM), mesothelioma diagnosis, mesothelioma treatments

Malignant mesothelioma of the tunica vaginalis testis: a rare case and review of literature

March 6, 2020 By Law Offices of Thomas J. Lamb, P.A.

Background:  Malignant mesothelioma of the tunica vaginalis is a rare tumour which comprises less than 1% of all mesotheliomas. Case presentation:  69-years old patient with painful hard mass and hydrocele in the right scrotum to whom a right hydrocelectomy was performed. Any history of scrotal trauma or exposure to asbestos was not … [Read more...]

Filed Under: Asbestos, Mesothelioma Tagged With: mesothelioma, mesothelioma diagnosis, mesothelioma treatments

CD70 Expression Correlates With a Worse Prognosis in Malignant Pleural Mesothelioma Patients

November 15, 2019 By Law Offices of Thomas J. Lamb, P.A.

Diffuse malignant mesothelioma of the pleura (MPM) is a highly aggressive tumour that typically is associated with short survival. CD70 and CD27 belong to the tumour necrosis factor (TNF) and the TNF receptor (TNFR) superfamily, respectively. Under physiological conditions, the tightly regulated interaction between CD70 and CD27 plays a … [Read more...]

Filed Under: Mesothelioma Tagged With: malignant pleural mesothelioma (MPM), mesothelioma, mesothelioma diagnosis

Owkin’s mesothelioma AI discovers new biomarkers from lung biopsy images

October 11, 2019 By Law Offices of Thomas J. Lamb, P.A.

By scanning thousands of tissue samples, [ Owkin’s mesothelioma AI program ] was able to help identify new types of patients with mesothelioma and predict which may respond better to certain therapies. Using whole biopsy slide images taken from nearly 3,000 patients with the aggressive and potentially fatal disease, [ Owkin’s mesothelioma AI … [Read more...]

Filed Under: Mesothelioma Tagged With: malignant pleural mesothelioma (MPM), mesothelioma, mesothelioma diagnosis, mesothelioma treatments

Diagnostic Value of Biopsy Sampling in Predicting Histology in Patients With Diffuse Malignant Pleural Mesothelioma

August 15, 2019 By Law Offices of Thomas J. Lamb, P.A.

BACKGROUND: The classification of diffuse malignant mesothelioma into epithelioid, biphasic, and sarcomatoid types is based on histologic patterns. The diagnosis is made on biopsies, and because of intratumoral heterogeneity, they may not be representative of the entire tumor. The number and volume of biopsies needed to reach diagnostic accuracy in … [Read more...]

Filed Under: Mesothelioma Tagged With: malignant pleural mesothelioma (MPM), mesothelioma, mesothelioma diagnosis, pleural mesothelioma

Dr. Goldberg Discusses the Diagnosis of Mesothelioma (Short Video)

April 23, 2019 By Law Offices of Thomas J. Lamb, P.A.

Sarah B. Goldberg, MD, MPH, assistant professor of medicine, Yale School of Medicine and Yale Cancer Center, discusses the diagnosis of mesothelioma. This is an extremely rare disease that is usually seen in patients with prior asbestos exposure, Goldberg says. However, mesothelioma can be seen occasionally in patients without prior exposure to … [Read more...]

Filed Under: Asbestos, Mesothelioma Tagged With: asbestos cancer, asbestos exposure, mesothelioma, mesothelioma diagnosis

Malignant pleural mesothelioma presenting with remitting–relapsing pleural effusions: report of two cases

February 26, 2018 By Law Offices of Thomas J. Lamb, P.A.

Pleural effusions are common and are associated with malignancy in one sixth of cases. Malignant pleural effusion (MPE) is typically persistent and progressive, prompting further investigations if the initial tests are not diagnostic. A spontaneously remitting effusion is commonly presumed to be benign, and further investigations may not be … [Read more...]

Filed Under: Asbestos, Mesothelioma Tagged With: asbestos cancer, malignant pleural mesothelioma (MPM), mesothelioma, mesothelioma diagnosis

Chemical profiling of primary mesothelioma cultures defines subtypes with different expression profiles and clinical responses

November 21, 2017 By Law Offices of Thomas J. Lamb, P.A.

Finding new treatment options for patients with malignant pleural mesothelioma is challenging due to the rarity and heterogeneity of this cancer type. The absence of druggable targets further complicates the development of new therapies. Current treatment options are therefore limited and prognosis remains poor. Experimental Design: We performed … [Read more...]

Filed Under: Mesothelioma Tagged With: malignant pleural mesothelioma (MPM), mesothelioma, mesothelioma diagnosis, pleural mesothelioma

Pleural effusion biomarkers and computed tomography findings in diagnosing malignant pleural mesothelioma: A retrospective study in a single center

November 1, 2017 By Law Offices of Thomas J. Lamb, P.A.

In this study, we aimed to examine the clinical value of the pleural effusion (PE) biomarkers, soluble mesothelin-related peptide (SMRP), cytokeratin 19 fragment (CYFRA 21–1) and carcinoembryonic antigen (CEA), and the utility of combining chest computed tomography (CT) findings with these biomarkers, in diagnosing malignant pleural mesothelioma … [Read more...]

Filed Under: Mesothelioma Tagged With: malignant pleural mesothelioma (MPM), mesothelioma, mesothelioma diagnosis, pleural mesothelioma

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