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Clinical-pathological characteristics and prognostic factors for malignant peritoneal mesothelioma in the elderly

June 23, 2022 By Law Offices of Thomas J. Lamb, P.A.

Background:  Malignant peritoneal mesothelioma (MPM) is a rare disease characterized by atypical symptoms, difficult diagnosis, variable course and poor prognosis, and it develops mainly in elderly individuals. The authors aimed to identify the clinical-pathological characteristics, prognosis, and prognostic factors in elderly [ malignant … [Read more...]

Filed Under: Mesothelioma Tagged With: mesothelioma, mesothelioma treatments, peritoneal mesothelioma

Biphasic Peritoneal Mesothelioma: A Lethal Clinical Entity

March 1, 2022 By Law Offices of Thomas J. Lamb, P.A.

Abstract:  Mesotheliomas are a rare malignancy of the serosal membrane. Mainly it affects the pleural surfaces followed by the second most common location, “peritoneum.” The disease follows an aggressive pattern of spread, and by the time the diagnosis is established, the condition significantly spreads to distant locations. Diagnosis of malignant … [Read more...]

Filed Under: Mesothelioma Tagged With: biphasic peritoneal mesothelioma, mesothelioma, peritoneal mesothelioma

Incidence, treatment and survival of malignant pleural and peritoneal mesothelioma: a population-based study

February 15, 2022 By Law Offices of Thomas J. Lamb, P.A.

Introduction:  Malignant mesothelioma (MM) is an aggressive cancer that primarily arises from the pleura (MPM) or peritoneum (MPeM), mostly due to asbestos exposure. This study reviewed the Dutch population-based incidence, treatment and survival since the national ban on asbestos in 1993. Materials and methods:  Patients with MPM or MPeM … [Read more...]

Filed Under: Asbestos, Mesothelioma Tagged With: malignant pleural mesothelioma (MPM), mesothelioma, mesothelioma diagnosis, mesothelioma treatments, peritoneal mesothelioma

Nivolumab versus placebo in patients with relapsed malignant mesothelioma (CONFIRM): a multicentre, double-blind, randomised, phase 3 trial

November 4, 2021 By Law Offices of Thomas J. Lamb, P.A.

Background:  No phase 3 trial has yet shown improved survival for patients with pleural or peritoneal malignant mesothelioma who have progressed following platinum-based chemotherapy. The aim of this study was to assess the efficacy and safety of nivolumab [(Opdivo)], an anti-PD-1 antibody, in these patients. Methods:  This was a multicentre, … [Read more...]

Filed Under: Mesothelioma Tagged With: malignant pleural mesothelioma (MPM), mesothelioma treatments, Opdivo, peritoneal mesothelioma

Drug Combo Promising in Rare Mesothelioma

July 28, 2021 By Law Offices of Thomas J. Lamb, P.A.

A combination of atezolizumab (Tecentriq) and bevacizumab appeared effective and safe in patients with advanced malignant peritoneal mesothelioma, according to results from a small single-arm trial. The combination achieved an objective response rate (ORR) of 40% in patients who had progressed on or were resistant to prior platinum-pemetrexed … [Read more...]

Filed Under: Mesothelioma Tagged With: mesothelioma, mesothelioma treatments, peritoneal mesothelioma

Osteopontin, GLUT1 and Ki-67 expression in malignant peritoneal mesothelioma: prognostic implications

July 7, 2021 By Law Offices of Thomas J. Lamb, P.A.

Background: Malignant peritoneal mesothelioma is the most common primary peritoneal neoplasm. The only universally recognised pathological prognostic factor is histopathological subtype. Prognostic markers based on patient features and clinical stages have been disappointing. Aims: To assess the prognostic role of several clinicopathological … [Read more...]

Filed Under: Mesothelioma Tagged With: mesothelioma, mesothelioma diagnosis, mesothelioma treatments, peritoneal mesothelioma

Anti-Mesothelin CAR T cell therapy for malignant mesothelioma

March 31, 2021 By Law Offices of Thomas J. Lamb, P.A.

AbstractMalignant mesothelioma (MM) is a treatment-resistant tumor originating in the mesothelial lining of the pleura or the abdominal cavity with very limited treatment options. More effective therapeutic approaches are urgently needed to improve the poor prognosis of MM patients. Chimeric Antigen Receptor (CAR) T cell therapy has emerged as a … [Read more...]

Filed Under: Mesothelioma Tagged With: mesothelioma, mesothelioma treatments, pericardial mesothelioma, peritoneal mesothelioma, pleural mesothelioma

Malignant Diffuse Mesothelioma in Women — A Study of 354 Cases

February 11, 2020 By Law Offices of Thomas J. Lamb, P.A.

We reviewed 354 cases of malignant diffuse mesothelioma (MM) in women from a database of 2858 histologically confirmed MM cases. There was a pleural predominance with 78% [ pleural malignant mesothelioma ] and 22% [ peritoneal malignant mesothelioma ]. The pleural tumors consisted of 72% epithelioid, 19% biphasic, and 9% sarcomatoid variant. The … [Read more...]

Filed Under: Asbestos, Mesothelioma Tagged With: asbestos cancer, asbestos exposure, mesothelioma, peritoneal mesothelioma, pleural mesothelioma

Effect of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy on Quality of Life in Patients with Peritoneal Mesothelioma

January 2, 2020 By Law Offices of Thomas J. Lamb, P.A.

Introduction:  Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) is an accepted treatment for peritoneal mesothelioma. In this study, we evaluated [ quality of life (QOL) ] after [ hyperthermic intraperitoneal chemotherapy (HIPEC) ] for peritoneal mesothelioma. Methods:  This was a prospective study performed … [Read more...]

Filed Under: Mesothelioma Tagged With: mesothelioma, mesothelioma treatments, peritoneal mesothelioma

50 Patients with Malignant Mesothelioma of Both the Pleura and Peritoneum: A Single-Institution Experience

December 27, 2019 By Law Offices of Thomas J. Lamb, P.A.

Background:  The most common sites of malignant mesothelioma are the pleura and peritoneum, but little is known about the incidence, prognosis, or treatment of patients with disease in both cavities. Previous series suggest that multimodality treatment improves overall survival for pleural or peritoneal disease, but studies typically exclude [ … [Read more...]

Filed Under: Mesothelioma Tagged With: mesothelioma, mesothelioma treatments, peritoneal mesothelioma, pleural mesothelioma

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