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Diagnostic Differentiation Between Two Rare Entities—Metastatic Peritoneal Mesothelioma With Duodenal Involvement and Duodenal Synovial Sarcoma: A Case Report

April 23, 2025 By Law Offices of Thomas J. Lamb, P.A.

Abstract:  This case report highlights the diagnostic challenges in distinguishing between metastatic peritoneal mesothelioma with duodenal involvement and synovial sarcoma of the duodenum, two rare and complex entities. A 59-year-old woman presented with nonspecific abdominal symptoms, and imaging revealed a heterogeneous lesion between the right … [Read more...]

Filed Under: Mesothelioma Tagged With: mesothelioma, peritoneal mesothelioma

A Review of Job Assignments and Asbestos Workplace Exposure Measurements for TAWP Mesothelioma Deaths Through 2011

March 28, 2025 By Law Offices of Thomas J. Lamb, P.A.

ABSTRACT Introduction: Asbestos workers have a higher risk of developing mesothelioma; however, few studies have looked at specific jobs and job locations within asbestos factories. The purpose of this study was to investigate asbestos exposure in different job locations of the Tyler, Texas asbestos plant to determine if there was a relationship … [Read more...]

Filed Under: Asbestos, Mesothelioma Tagged With: asbestos exposure, mesothelioma

Recent Advances in Mesothelioma Treatment: Immunotherapy, Advanced Cell Therapy, and Other Innovative Therapeutic Modalities

February 20, 2025 By Law Offices of Thomas J. Lamb, P.A.

Mesothelioma is a malignant condition arising from the pleura and peritoneum that is closely related to asbestos exposure. Due to the prolonged time needed for one to fully develop mesothelioma, difficulty in diagnosing this condition early, its quick progression once manifested, and the limited treatment options, the prognosis for this condition … [Read more...]

Filed Under: Mesothelioma Tagged With: mesothelioma, mesothelioma treatments

Treatment of Pleural Mesothelioma: ASCO Guideline Update

February 3, 2025 By Law Offices of Thomas J. Lamb, P.A.

Since the initial [American Society of Clinical Oncologists (ASCO)] clinical practice guideline on the treatment of malignant pleural mesothelioma (PM) was published in 2018 considerable progress has been made which has changed not only the management but even the name of this disease. This guideline update focuses on four key areas: the role of … [Read more...]

Filed Under: Mesothelioma Tagged With: malignant pleural mesothelioma (MPM), mesothelioma, mesothelioma treatments

The presence of pleural effusion is an independent prognostic factor in patients with malignant pleural mesothelioma

January 7, 2025 By Law Offices of Thomas J. Lamb, P.A.

Abstract:  Malignant pleural mesothelioma (MPM) is a rare form of thoracic malignancy with a poor prognosis. Pleural effusion (PE) occurs in the majority of patients with MPM; however, its impact on MPM outcomes remains controversial. We searched for eligible patients from the Surveillance, Epidemiology, and End Results (SEER) database, and … [Read more...]

Filed Under: Mesothelioma Tagged With: malignant pleural mesothelioma (MPM), mesothelioma, mesothelioma diagnosis

Diffuse Pleural Mesothelioma: A Challenge in Early Diagnosis

December 17, 2024 By Law Offices of Thomas J. Lamb, P.A.

Abstract:  We present the clinical case of a 58-year-old female patient, a smoker with occupational exposure to respiratory toxins, who was admitted to our clinic following evaluation in an emergency department, where she was diagnosed with a moderate right pleural effusion. Upon admission, the patient exhibited respiratory symptoms, including … [Read more...]

Filed Under: Asbestos, Mesothelioma Tagged With: dyspnea, malignant pleural mesothelioma (MPM), mesothelioma, mesothelioma diagnosis, pleural mesothelioma

Treatment of Malignant Pleural Mesothelioma: American Society of Clinical Oncology Clinical Practice Guideline

November 21, 2024 By Law Offices of Thomas J. Lamb, P.A.

Introduction The purpose of this guideline is to provide recommendations for the management of patients with malignant pleural mesothelioma (MPM), an aggressive tumor with a poor prognosis. In the United States, about 3,000 new cases are diagnosed each year. The median overall survival of patients with advanced surgically unresectable disease is … [Read more...]

Filed Under: Mesothelioma Tagged With: mesothelioma, mesothelioma diagnosis, mesothelioma treatments

FDA Approves Pembrolizumab Plus Chemo for Unresectable Advanced or Metastatic Malignant Pleural Mesothelioma

September 19, 2024 By Law Offices of Thomas J. Lamb, P.A.

The FDA has approved [ Keytruda (pembrolizumab) ] plus pemetrexed and platinum chemotherapy in the frontline treatment of patients with unresectable advanced or metastatic malignant pleural mesothelioma. Data from the phase 2/3 KEYNOTE-483 study (NCT02784171) showed that [ Keytruda (pembrolizumab) ] plus chemotherapy (n = 222) significantly … [Read more...]

Filed Under: Mesothelioma Tagged With: Keytruda, malignant pleural mesothelioma (MPM), mesothelioma, mesothelioma treatments

Chemotherapy increases CDA expression and sensitizes malignant pleural mesothelioma cells to capecitabine treatment

September 6, 2024 By Law Offices of Thomas J. Lamb, P.A.

Abstract:  The combination of cisplatin and pemetrexed remains the gold standard chemotherapy for malignant pleural mesothelioma (MPM), although resistance and poor response pose a significant challenge. Cytidine deaminase (CDA) is a key enzyme in the nucleotide salvage pathway and is involved in the adaptive stress response to chemotherapy. The … [Read more...]

Filed Under: Asbestos Tagged With: chemotherapy, malignant pleural mesothelioma (MPM), mesothelioma, mesothelioma treatments

Challenging the Norm: Occurrence of Synchronous Pleural and Peritoneal Mesothelioma in a Female Patient

August 22, 2024 By Law Offices of Thomas J. Lamb, P.A.

Abstract:  Here, we present a unique case involving a female patient in her 40s with synchronous malignant pleural and peritoneal mesothelioma, despite lacking a history of asbestos exposure. The patient’s initial symptoms included dyspnoea, chest pain, cough, fever, appetite loss, and weight loss over a month. Clinical evaluation led to the … [Read more...]

Filed Under: Mesothelioma Tagged With: mesothelioma, peritoneal mesothelioma, pleural mesothelioma

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1908 Eastwood Road, Suite 225
Wilmington, North Carolina 28403
910-256-2971 | 800-426-9535
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