Nivolumab plus ipilimumab conferred a durable survival benefit compared with chemotherapy as first-line treatment for unresectable malignant pleural mesothelioma, according to randomized phase 3 trial data released by the manufacturer. The open-label, multicenter CheckMate-743 trial included 605 patients who received six cycles of pemetrexed and … [Read more...]
Nivolumab/Ipilimumab Demonstrates Durable OS Benefit in Malignant Pleural Mesothelioma
Nivolumab (Opdivo) plus ipilimumab (Yervoy) significantly improved overall survival (OS) versus chemotherapy in the first-line treatment of patients with unresectable malignant pleural mesothelioma, according to findings from a prespecified analysis of the phase 3 CheckMate-743 trial (NCT02899299) that were presented during the 2020 International … [Read more...]
Keytruda / Opdivo / Yervoy: May Cause Vision Loss, Retinal Detachment
A developing drug safety issue is presented in this news report, “FDA Considers Label Changes for Keytruda, Opdivo and Yervoy”, which was posted July 12, 2017 on the Regulatory Affairs Professional Society (RAPS) website. Here are some contextual details provided by reporter Zachary Brennan in this article: The consideration for changing the … [Read more...]