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Merck reports positive data from malignant pleural mesothelioma trial

May 25, 2023 By Law Offices of Thomas J. Lamb, P.A.

Merck and the Canadian Cancer Trials Group (CCTG) have reported positive data from the Phase II/III CCTG IND.227/KEYNOTE-483 trial of Keytruda, along with chemotherapy, as first-line treatment for advanced malignant pleural mesothelioma patients. The open-label, randomised Phase II/III trial has been designed for assessing the combination of … [Read more...]

Filed Under: Mesothelioma Tagged With: malignant pleural mesothelioma (MPM), mesothelioma, mesothelioma treatments

Incidence of Malignant Pleural Mesothelioma Decreased in the United States During 2004 to 2019

April 14, 2023 By Law Offices of Thomas J. Lamb, P.A.

Despite a rising global incidence, long-term data reveal the U.S. [ incidence rate of pleural mesothelioma ] has decreased and overall survival for patients with mesothelioma is improving, according to a study presented at the annual meeting of the European Lung Cancer Congress, held from March 29 to April 1 in Copenhagen, Denmark. Mohamed … [Read more...]

Filed Under: Mesothelioma Tagged With: malignant pleural mesothelioma (MPM), mesothelioma, mesothelioma diagnosis

A Gelatinous Pleural Effusion as a Diagnostic Clue

March 16, 2023 By Law Offices of Thomas J. Lamb, P.A.

Pleural effusion is a common presentation of several pathologies, and the determination of its cause is facilitated by macroscopic, biochemical, microbiological, and cellular analysis. A systematic approach to analyzing the fluid allows for a reduction in clinical diagnoses. Only a select number of diagnoses can be established definitively by … [Read more...]

Filed Under: Mesothelioma Tagged With: malignant pleural mesothelioma (MPM), mesothelioma, mesothelioma diagnosis

Pleural Mesothelioma: A Rapid Evolution of an Indolent Disease

January 31, 2023 By Law Offices of Thomas J. Lamb, P.A.

Mesothelioma is a rare and insidious neoplasm and is characterized by its highly malignant and aggressive nature. The most common etiology is asbestos exposure, but there are some reports without known asbestos exposure and other factors leading to malignant pleural mesothelioma (MPM). Here, we present the case of a 58-year-old woman with … [Read more...]

Filed Under: Asbestos, Mesothelioma Tagged With: asbestos exposure, malignant pleural mesothelioma (MPM), mesothelioma, pleural mesothelioma

Pembrolizumab / Lenvatinib Combo Shows Positive Clinical Activity in Recurrent Pleural Mesothelioma

September 16, 2022 By Law Offices of Thomas J. Lamb, P.A.

The combination of pembrolizumab (Keytruda), and lenvatinib (Lenvima) demonstrated promising clinical activity with no unexpected toxicities in patients with malignant pleural mesothelioma (MPM), according to results from the PEMMELA study (NCT04287829) presented at the International Association for the Study of Lung Cancer 2022 World … [Read more...]

Filed Under: Mesothelioma Tagged With: Keytruda, Lenvima, malignant pleural mesothelioma (MPM), mesothelioma, mesothelioma treatments

Galinpepimut-S Plus Nivolumab Extends Survival in Malignant Pleural Mesothelioma

August 8, 2022 By Law Offices of Thomas J. Lamb, P.A.

The combination of galinpepimut-S and nivolumab (Opdivo) was found to extend survival in patients with malignant pleural mesothelioma who were either refractory to, or who had relapsed after, at least 1 line of standard therapy, according to updated data from a phase 1 trial (NCT04040231). The median overall survival (OS), which was calculated … [Read more...]

Filed Under: Mesothelioma Tagged With: malignant pleural mesothelioma (MPM), mesothelioma, mesothelioma treatments

Second Surgery for Recurrent Malignant Pleural Mesothelioma after Multimodality Treatment: A Systematic Review

July 11, 2022 By Law Offices of Thomas J. Lamb, P.A.

Malignant pleural mesothelioma (MPM) is an aggressive asbestos-related tumour with poor prognosis. To date, a multimodality treatment, including chemotherapy and surgery, with or without radiotherapy, is the gold standard therapy for selected patients with epithelioid and early-stage MPM. In this setting, the goal of surgery is to achieve the … [Read more...]

Filed Under: Mesothelioma Tagged With: malignant pleural mesothelioma (MPM), mesothelioma, mesothelioma treatments

Unexplained Pleural Effusion Leads to the Revelation of a Malignant Mesothelioma: A Case Report

May 4, 2022 By Law Offices of Thomas J. Lamb, P.A.

Abstract:  Malignant mesothelioma is a rare and aggressive cancer that usually affects subjects with prior asbestos exposure, a major risk factor that has been widely known as carcinogenic, and its use is now controlled if not banned in many areas of the world. Malignant mesothelioma originates from mesothelial surface cells covering the serous … [Read more...]

Filed Under: Asbestos, Mesothelioma Tagged With: asbestos cancer, asbestos exposure, malignant pleural mesothelioma (MPM), mesothelioma, pleural effusions

First-line nivolumab plus ipilimumab versus chemotherapy in patients with unresectable malignant pleural mesothelioma: 3-year outcomes from CheckMate 743

February 22, 2022 By Law Offices of Thomas J. Lamb, P.A.

Background: In the phase 3 CheckMate 743 study (NCT02899299), first-line nivolumab plus ipilimumab significantly improved overall survival (OS) versus chemotherapy in patients with unresectable malignant pleural mesothelioma [(unresectable MPM)]. We report updated data with 3-year minimum follow-up. Patients and methods: Adults with previously … [Read more...]

Filed Under: Mesothelioma Tagged With: ipilimumab, malignant pleural mesothelioma (MPM), mesothelioma, mesothelioma treatments, nivolumab

Incidence, treatment and survival of malignant pleural and peritoneal mesothelioma: a population-based study

February 15, 2022 By Law Offices of Thomas J. Lamb, P.A.

Introduction:  Malignant mesothelioma (MM) is an aggressive cancer that primarily arises from the pleura (MPM) or peritoneum (MPeM), mostly due to asbestos exposure. This study reviewed the Dutch population-based incidence, treatment and survival since the national ban on asbestos in 1993. Materials and methods:  Patients with MPM or MPeM … [Read more...]

Filed Under: Asbestos, Mesothelioma Tagged With: malignant pleural mesothelioma (MPM), mesothelioma, mesothelioma diagnosis, mesothelioma treatments, peritoneal mesothelioma

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