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Multimodality Therapy Including Pleurectomy/Decortication in Pleural Mesothelioma: Long-Term Outcomes in 152 Consecutive Patients A Retrospective Cohort Study

March 6, 2025 By Law Offices of Thomas J. Lamb, P.A.

Objective:  Evaluate the long-term outcomes of pleurectomy decortication, systemic chemotherapy and prophylactic radiotherapy in pleural mesothelioma (PM). Summary background data:  There is no known cure for PM and cytoreductive surgery remains controversial. Methods:  Retrospective analysis of a cohort of patients treated consecutively … [Read more...]

Filed Under: Mesothelioma Tagged With: chemotherapy, decortication, mesothelioma treatments, pleural mesothelioma, pleurectomy, radiotherapy

Diffuse Pleural Mesothelioma: A Challenge in Early Diagnosis

December 17, 2024 By Law Offices of Thomas J. Lamb, P.A.

Abstract:  We present the clinical case of a 58-year-old female patient, a smoker with occupational exposure to respiratory toxins, who was admitted to our clinic following evaluation in an emergency department, where she was diagnosed with a moderate right pleural effusion. Upon admission, the patient exhibited respiratory symptoms, including … [Read more...]

Filed Under: Asbestos, Mesothelioma Tagged With: dyspnea, malignant pleural mesothelioma (MPM), mesothelioma, mesothelioma diagnosis, pleural mesothelioma

Immunotherapy for Treatment of Pleural Mesothelioma: Current and Emerging Therapeutic Strategies

October 11, 2024 By Law Offices of Thomas J. Lamb, P.A.

Pleural mesothelioma is a rare malignancy associated with asbestos exposure and very poor prognosis, with a 5-year overall survival of 12%. Outcomes may vary according to stage at time of diagnosis and histologic subtype. Most recently, clinical trials utilizing dual checkpoint inhibitor regimens and chemotherapy in combination with immune … [Read more...]

Filed Under: Mesothelioma Tagged With: immunotherapy, mesothelioma treatments, pleural mesothelioma

Challenging the Norm: Occurrence of Synchronous Pleural and Peritoneal Mesothelioma in a Female Patient

August 22, 2024 By Law Offices of Thomas J. Lamb, P.A.

Abstract:  Here, we present a unique case involving a female patient in her 40s with synchronous malignant pleural and peritoneal mesothelioma, despite lacking a history of asbestos exposure. The patient’s initial symptoms included dyspnoea, chest pain, cough, fever, appetite loss, and weight loss over a month. Clinical evaluation led to the … [Read more...]

Filed Under: Mesothelioma Tagged With: mesothelioma, peritoneal mesothelioma, pleural mesothelioma

Extended pleurectomy decortication and chemotherapy versus chemotherapy alone for pleural mesothelioma (MARS 2): a phase 3 randomised controlled trial

July 18, 2024 By Law Offices of Thomas J. Lamb, P.A.

Background:  Extended pleurectomy decortication for complete macroscopic resection for pleural mesothelioma has never been evaluated in a randomised trial. The aim of this study was to compare outcomes after extended pleurectomy decortication plus chemotherapy versus chemotherapy alone. Methods:  MARS 2 was a phase 3, national, multicentre, … [Read more...]

Filed Under: Mesothelioma Tagged With: chemotherapy, decortication, mesothelioma, mesothelioma treatments, pleural mesothelioma, pleurectomy

Malignant Pleural Mesothelioma: Analysis of 70 Cases in the Last Decade

June 26, 2024 By Law Offices of Thomas J. Lamb, P.A.

Malignant Pleural Mesothelioma (MPM) is an aggressive tumor linked to asbestos exposure, with a latency period of about 40 years before symptoms appear. Despite affecting a minority of exposed individuals, its risk escalates with prolonged exposure. Originating from mesothelial cells, [ Malignant Pleural Mesothelioma (MPM) ] affected 30,870 … [Read more...]

Filed Under: Mesothelioma Tagged With: mesothelioma, pleural mesothelioma

Predictive potential of MRI in differentiating the predominant component in biphasic pleural mesothelioma

May 31, 2024 By Law Offices of Thomas J. Lamb, P.A.

Purpose:  To assess the potential of apparent diffusion coefficient (ADC) values derived from diffusion weighted (DW) MRI preoperatively to predict the predominant histologic component among biphasic pleural mesothelioma (PM) tumors. Methods:  ADC maps were generated from DW MRI scans. Histology and predominant component of [ biphasic pleural … [Read more...]

Filed Under: Mesothelioma Tagged With: mesothelioma, pleural mesothelioma

Validation of Inflammatory Prognostic Biomarkers in Pleural Mesothelioma

April 17, 2024 By Law Offices of Thomas J. Lamb, P.A.

Asbestos exposure is known as the main elicitor of pleural mesothelioma (PM) development. The pathology’s rarity, wide range of growth patterns, and devastating prognosis have hindered a standardized treatment to date. This study intended to determine possible prognosticators contributing to adjusting the treatment allocation. This initiated the … [Read more...]

Filed Under: Mesothelioma Tagged With: mesothelioma, mesothelioma treatments, pleural mesothelioma

Impact of Surgery on Disease Progression and Survival of Patients with Pleural Mesothelioma

March 11, 2024 By Law Offices of Thomas J. Lamb, P.A.

BACKGROUND:  The effects of surgery on the survival of patients with pleural mesothelioma remain poorly understood. We compared the therapeutic outcomes of patients receiving neoadjuvant chemotherapy followed by surgery or refusing surgery for pleural mesothelioma. METHODS:  This retrospective study included consecutive patients who were … [Read more...]

Filed Under: Mesothelioma Tagged With: mesothelioma, mesothelioma treatments, pleural mesothelioma

Pegargiminase Confers Survival Benefit in Nonepithelioid Pleural Mesothelioma

February 22, 2024 By Law Offices of Thomas J. Lamb, P.A.

Adding [ new treatment drug ] pegargiminase to standard chemotherapy can improve outcomes in patients with chemotherapy-naïve, nonepithelioid pleural mesothelioma, according to research published in JAMA Oncology. [Szlosarek PW, Creelan BC, Sarkodie T, et al. Pegargiminase plus first-line chemotherapy in patients with nonepithelioid pleural … [Read more...]

Filed Under: Mesothelioma Tagged With: mesothelioma, mesothelioma treatments, pegargiminase, pleural mesothelioma

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1908 Eastwood Road, Suite 225
Wilmington, North Carolina 28403
910-256-2971 | 800-426-9535
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