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Extended pleurectomy decortication and chemotherapy versus chemotherapy alone for pleural mesothelioma (MARS 2): a phase 3 randomised controlled trial

July 18, 2024 By Law Offices of Thomas J. Lamb, P.A.

Background:  Extended pleurectomy decortication for complete macroscopic resection for pleural mesothelioma has never been evaluated in a randomised trial. The aim of this study was to compare outcomes after extended pleurectomy decortication plus chemotherapy versus chemotherapy alone. Methods:  MARS 2 was a phase 3, national, multicentre, … [Read more...]

Filed Under: Mesothelioma Tagged With: chemotherapy, decortication, mesothelioma, mesothelioma treatments, pleural mesothelioma, pleurectomy

Malignant Pleural Mesothelioma: Analysis of 70 Cases in the Last Decade

June 26, 2024 By Law Offices of Thomas J. Lamb, P.A.

Malignant Pleural Mesothelioma (MPM) is an aggressive tumor linked to asbestos exposure, with a latency period of about 40 years before symptoms appear. Despite affecting a minority of exposed individuals, its risk escalates with prolonged exposure. Originating from mesothelial cells, [ Malignant Pleural Mesothelioma (MPM) ] affected 30,870 … [Read more...]

Filed Under: Mesothelioma Tagged With: mesothelioma, pleural mesothelioma

Predictive potential of MRI in differentiating the predominant component in biphasic pleural mesothelioma

May 31, 2024 By Law Offices of Thomas J. Lamb, P.A.

Purpose:  To assess the potential of apparent diffusion coefficient (ADC) values derived from diffusion weighted (DW) MRI preoperatively to predict the predominant histologic component among biphasic pleural mesothelioma (PM) tumors. Methods:  ADC maps were generated from DW MRI scans. Histology and predominant component of [ biphasic pleural … [Read more...]

Filed Under: Mesothelioma Tagged With: mesothelioma, pleural mesothelioma

Validation of Inflammatory Prognostic Biomarkers in Pleural Mesothelioma

April 17, 2024 By Law Offices of Thomas J. Lamb, P.A.

Asbestos exposure is known as the main elicitor of pleural mesothelioma (PM) development. The pathology’s rarity, wide range of growth patterns, and devastating prognosis have hindered a standardized treatment to date. This study intended to determine possible prognosticators contributing to adjusting the treatment allocation. This initiated the … [Read more...]

Filed Under: Mesothelioma Tagged With: mesothelioma, mesothelioma treatments, pleural mesothelioma

Impact of Surgery on Disease Progression and Survival of Patients with Pleural Mesothelioma

March 11, 2024 By Law Offices of Thomas J. Lamb, P.A.

BACKGROUND:  The effects of surgery on the survival of patients with pleural mesothelioma remain poorly understood. We compared the therapeutic outcomes of patients receiving neoadjuvant chemotherapy followed by surgery or refusing surgery for pleural mesothelioma. METHODS:  This retrospective study included consecutive patients who were … [Read more...]

Filed Under: Mesothelioma Tagged With: mesothelioma, mesothelioma treatments, pleural mesothelioma

Pegargiminase Confers Survival Benefit in Nonepithelioid Pleural Mesothelioma

February 22, 2024 By Law Offices of Thomas J. Lamb, P.A.

Adding [ new treatment drug ] pegargiminase to standard chemotherapy can improve outcomes in patients with chemotherapy-naïve, nonepithelioid pleural mesothelioma, according to research published in JAMA Oncology. [Szlosarek PW, Creelan BC, Sarkodie T, et al. Pegargiminase plus first-line chemotherapy in patients with nonepithelioid pleural … [Read more...]

Filed Under: Mesothelioma Tagged With: mesothelioma, mesothelioma treatments, pegargiminase, pleural mesothelioma

FDA Fast Tracks UV1, Ipilimumab, and Nivolumab in Malignant Mesothelioma

February 8, 2024 By Law Offices of Thomas J. Lamb, P.A.

The FDA has granted a fast track designation to the combination of UV1 with ipilimumab and nivolumab for the treatment of patients with unresectable malignant pleural mesothelioma. This regulatory decision is supported by findings from the phase 2 NIPU trial which is evaluating UV1 in patients with unresectable malignant pleural mesothelioma. … [Read more...]

Filed Under: Mesothelioma Tagged With: ipilimumab, malignant pleural mesothelioma (MPM), mesothelioma, mesothelioma treatments, nivolumab, pleural mesothelioma, UV1

A Complete Response to Pembrolizumab in Malignant Peritoneal Mesothelioma: A Case Report

January 24, 2024 By Law Offices of Thomas J. Lamb, P.A.

Abstract:  Malignant peritoneal mesothelioma (MPeM) is a rare cancer of the peritoneum with a poor prognosis and nonspecific clinical course. We discuss a case of MPeM in a 59-year-old male who presented with abdominal pain and distension, without any known previous asbestos exposure. The diagnosis was made after a second biopsy finally confirmed … [Read more...]

Filed Under: Mesothelioma Tagged With: mesothelioma, mesothelioma treatments, pembrolizumab, peritoneal mesothelioma

Niraparib plus Dostarlimab in Pleural Mesothelioma or Non-Small Cell Lung Cancer harboring HRR mutations: interim results of the UNITO-001 phase 2 prospective trial

January 23, 2024 By Law Offices of Thomas J. Lamb, P.A.

Introduction: Treatment of homologous recombination repair deficient (HRD)-tumours with PARP inhibitors has the potential to further increase tumour immunogenicity, suggesting a synergistic effect with immunotherapy. Here we present the preliminary results of niraparib in combination with dostarlimab for pleural mesothelioma (PM) or non-small cell … [Read more...]

Filed Under: Mesothelioma Tagged With: mesothelioma, mesothelioma treatments, nira, pleural mesothelioma

Toxicities Potentially Linked to Combination Immunotherapy for Mesothelioma

January 12, 2024 By Law Offices of Thomas J. Lamb, P.A.

The [ immunotherapy combination ] of ipilimumab and nivolumab may result in a higher levels of toxicities in patients with unresectable pleural mesothelioma than was reported in the CheckMate 743 trial, according to a recent study published by McNamee et al in the Journal of Thoracic Oncology. Background: Australia has one of the highest rates … [Read more...]

Filed Under: Mesothelioma Tagged With: mesothelioma, mesothelioma treatments, pleural mesothelioma

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1908 Eastwood Road, Suite 225
Wilmington, North Carolina 28403
910-256-2971 | 800-426-9535
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