We continue to monitor the medical literature for any Padcev skin reaction case report involving toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS). In this post, we cover two Padcev-induced TEN / SJS cases where the patient died from their Padcev side effects. We start with a Case Report item published by the Journal of The … [Read more...]
Adding Atezolizumab to Neoadjuvant Cisplatin-Pemetrexed a Feasible Option in Malignant Pleural Mesothelioma
A three-agent neoadjuvant regimen that combines a PD-L1 inhibitor with chemotherapy appears feasible for patients with malignant pleural mesothelioma, according to an ongoing phase I trial. The findings [ about neoadjuvant therapy ] were presented at the International Association for the Study of Lung Cancer virtual World Conference on Lung Cancer, … [Read more...]
Drug Regulator MHRA Imposes More Xeljanz Use Limitations in October 2021
In this Drug Safety Update document, “Tofacitinib (Xeljanz▼): new measures to minimise risk of major adverse cardiovascular events and malignancies”, the UK’s Medicines and Healthcare products Regulatory Agency (MHRA) took new regulatory action regarding the Xeljanz risk of cardiovascular events as well as the Xeljanz risk of cancers, or … [Read more...]
Nivo/Ipi Combo Now ‘Standard of Care’ in Mesothelioma
The [ combination immunotherapy consisting ] of nivolumab (Opdivo) and ipilimumab (Yervoy) offers a durable, long-term survival benefit over chemotherapy for patients with unresectable malignant pleural mesothelioma (MPM), confirms a 3-year updated analysis of the CheckMate 743 trial. After 3 years, 23% of patients who received combination … [Read more...]
Benzene Linked to Non-Hodgkin Lymphoma According to New Review of Past Studies
Exposure to benzene has been known to cause acute myelogenous leukemia (AML) and myelodysplastic syndrome (MDS). Now, as a result of new medical research has found a statistically significant association between exposure to benzene and non-Hodgkin lymphoma. Medical researchers recently examined the potential link between benzene exposure and … [Read more...]
BIA-ALCL Current Recommendations and Potential Future FDA Guidance Changes
History of BIA-ALCL In 2011, the Food and Drug Administration (FDA) reported 34 cases worldwide of Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL), bringing this unique disease into the public eye for the first time. Since then, BIA-ALCL has been recognized internationally as a distinct type of cancer, and prompted the 2019 … [Read more...]
New EPA Administrator Makes PFAS Contamination Issue A Priority
On March 11, 2021, Michael Regan, the former North Carolina Department of Environmental Quality (DEQ) Secretary was sworn into office as the new head of the United States Environmental Protection Agency (EPA). Since this transition from the NC DEQ to US EPA Administrator, Regan has made it clear per- and polyfluoroalkyl substances (PFAS) … [Read more...]
Some Information About Our Monthly Law Firm Newsletter
The Lamb Law Office Newsletter is a monthly communication from our law firm to help keep you up to date with some of the cases that we are working on for clients at the present time. In addition, we provide at least one information resource item per month, which you or someone you know might find helpful from time to time. Past … [Read more...]
Notice Violation Issued to Chemours After Failure to Properly Remove PFAS Contamination
According to a January 2021 article "N.C. regulators issue notice of violation to Chemours", the company received a violation notice regarding a newly-installed treatment system that failed to remove PFAS contamination at the Fayetteville Works site. As mentioned in previous articles, the main offender for per- and polyfluoroalkyl substances (PFAS) … [Read more...]
Additional PFAS Testing Petition Denied by the EPA
Since our last article, “PFAS Levels in Cape Fear Remain Largely the Same, Despite Emission Cuts“, the Cape Fear region continues to experience high levels of “forever chemicals” in their water supply. Despite requests for additional PFAS testing, no additional regulations have been put in place. As mentioned in previous articles, the main … [Read more...]
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