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Multimodality Therapy Including Pleurectomy/Decortication in Pleural Mesothelioma: Long-Term Outcomes in 152 Consecutive Patients A Retrospective Cohort Study

March 6, 2025 By Law Offices of Thomas J. Lamb, P.A.

Objective:  Evaluate the long-term outcomes of pleurectomy decortication, systemic chemotherapy and prophylactic radiotherapy in pleural mesothelioma (PM). Summary background data:  There is no known cure for PM and cytoreductive surgery remains controversial. Methods:  Retrospective analysis of a cohort of patients treated consecutively … [Read more...]

Filed Under: Mesothelioma Tagged With: chemotherapy, decortication, mesothelioma treatments, pleural mesothelioma, pleurectomy, radiotherapy

Chemotherapy increases CDA expression and sensitizes malignant pleural mesothelioma cells to capecitabine treatment

September 6, 2024 By Law Offices of Thomas J. Lamb, P.A.

Abstract:  The combination of cisplatin and pemetrexed remains the gold standard chemotherapy for malignant pleural mesothelioma (MPM), although resistance and poor response pose a significant challenge. Cytidine deaminase (CDA) is a key enzyme in the nucleotide salvage pathway and is involved in the adaptive stress response to chemotherapy. The … [Read more...]

Filed Under: Asbestos Tagged With: chemotherapy, malignant pleural mesothelioma (MPM), mesothelioma, mesothelioma treatments

Extended pleurectomy decortication and chemotherapy versus chemotherapy alone for pleural mesothelioma (MARS 2): a phase 3 randomised controlled trial

July 18, 2024 By Law Offices of Thomas J. Lamb, P.A.

Background:  Extended pleurectomy decortication for complete macroscopic resection for pleural mesothelioma has never been evaluated in a randomised trial. The aim of this study was to compare outcomes after extended pleurectomy decortication plus chemotherapy versus chemotherapy alone. Methods:  MARS 2 was a phase 3, national, multicentre, … [Read more...]

Filed Under: Mesothelioma Tagged With: chemotherapy, decortication, mesothelioma, mesothelioma treatments, pleural mesothelioma, pleurectomy

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1908 Eastwood Road, Suite 225
Wilmington, North Carolina 28403
910-256-2971 | 800-426-9535
TJL@LambLawOffice.com

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