There is new medical research concerning pancreatic cancer linked to diabetes medicines in the DPP-4 inhibitor drug class. In more detail, the use of dipeptidyl peptidase-4 inhibitors (DPP-4i) diabetes medicines may be associated with an increased risk for pancreatic cancer in patients with newly diagnosed type 2 diabetes. This finding comes … [Read more...]
Diabetes Drugs In DPP-4 Inhibitor Class Significantly Increase Risk Of Crohn’s Disease (CD)
The medical journal Annals of Pharmacotherapy has published an article, “Dipeptidyl Peptidase-4 Inhibitors and Inflammatory Bowel Disease Risk: A Meta-analysis”, which concludes that dipeptidyl peptidase-4 (DPP-4) inhibitors increase the risk of Crohn’s disease (CD). It goes on to point out that these DPP-4 inhibitor diabetes drugs, such as … [Read more...]
Lower Limb Amputations From All SGLT2 Inhibitors, or Just Invokana?
A “Black-Box Warning” about the increased risk of lower limb amputations was added to the drug labels for Invokana and Invokamet in July 2017. Since that time there has been a mix of opinions expressed in the medical literature about whether or not lower limb amputations are a side effect of all diabetes medicines in the sodium-glucose … [Read more...]
Amputations Are Diabetes Drugs Side Effects For SGLT2 Inhibitors Class
There seems to be an increasing degree of acknowledgement in the medical literature that these lower limb amputations are drug-class side effects of SGLT2 inhibitors class diabetes medicines such as Jardiance and Farxiga in addition to Invokana. For example, from this recent Medscape news report, “Canagliflozin (Invokana) Gets FDA Nod for CV … [Read more...]
Fournier’s Gangrene: Side Effect For Invokana, Farxiga, And Jardiance
From this August 29, 2018 Drug Safety Communication, “FDA warns about rare occurrences of a serious infection of the genital area with SGLT2 inhibitors for diabetes”, we get the following details about this new safety issue for Invokana, Farxiga, Jardiance, and similar diabetes drugs: Fournier’s gangrene is an extremely rare but life-threatening … [Read more...]
Pradaxa Liver Injury: Label Changes Warning About This Increased Risk
We are watching to see whether the FDA and/or European drug regulators require a Pradaxa liver injury label change adding a new warning about an increased risk of acute liver failure and drug-induced hepatitis — like what was done in Japan last year and is being done now in Canada. In May 2018 Health Canada announced that their Pradaxa drug … [Read more...]
Will FDA Order Uloric Recall Requested In June 2018 By Public Citizen
The consumer advocacy group Public Citizen asserts that a FDA Uloric recall is necessary following results of a large postmarketing study that showed higher rates of fatal cardiovascular (CV) events and all-cause mortality in patients taking the drug. More exactly, it is the Cardiovascular Safety of Febuxostat and Allopurinol in Patients with Gout … [Read more...]
Health Canada: OFEV Label Will Add Drug-Induced Liver Injury Warning
On January 11, 2018 Health Canada issued a Dear Healthcare Professional Letter communication titled “OFEV (nintedanib) – Risk of Drug-Induced Liver Injury and the Need for Regular Monitoring of Liver Function”. From the Background Information section of that new Health Canada document we get this overview of the safety issue: OFEV (nintedanib) … [Read more...]
New Heartburn Drugs Study Shows 33% Increased Risk of Kidney Problems
Previous Research on PPIs & Kidney Damage Several studies have been published in the past several years concerning the relationship between chronic kidney disease (CKD) and proton pump inhibitors (PPIs) such as Nexium, Prilosec, and Prevacid. The table below identifies the year, title, and results of three recent studies on PPIs and kidney … [Read more...]
2017 Medical Articles: Association Of Melanoma With Viagra And Cialis
The five brand name erectile dysfunction (ED) drugs in the phosphodiesterase 5 (PDE-5) inhibitors class are Viagra (sildenafil), Cialis (tadalafil), Levitra (vardenafil), Staxyn (vardenafil), and Stendra (avanafil). Cialis is also prescribed sometimes when doctors see the signs and symptoms of benign prostatic hyperplasia (BPH). Two other … [Read more...]
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