Law Offices of Thomas J. Lamb

  • About Firm
  • Practice Areas
  • Free Case Evaluation
  • Quick Contact Form
  • Frequently Asked Questions
  • Attorney Tom Lamb

Abemaciclib for Previously Treated Patients With p16ink4A-Deficient Mesothelioma

April 18, 2022 By Law Offices of Thomas J. Lamb, P.A.

As reported in The Lancet Oncology by Dean A. Fennell, FRCP, and colleagues, a phase II trial (MiST2) showed the activity of [ Verzenio (abemaciclib) ] in previously treated patients with p16ink4A-deficient malignant mesothelioma.

As stated by the investigators, “Genetically stratified therapy for malignant mesothelioma is unavailable. Mesotheliomas frequently harbor loss of the chromosome 9p21.3 locus (CDKN2A–MTAP), which is associated with shorter overall survival due to loss of the tumour suppressor p16ink4A, an endogenous suppressor of CDK4 and CDK6. Genetic restoration of p16ink4A suppresses mesothelioma in preclinical models, underpinning the rationale for targeting CDK4 and CDK6 in p16ink4A-negative mesothelioma.”

In the study, 26 evaluable patients who had received at least one course of platinum-based chemotherapy were enrolled from two UK centers between September 2019 and March 2020. Treatment consisted of [ Verzenio (abemaciclib) ] at 200 mg twice daily administered continuously in 28-day cycles for 24 weeks. The primary endpoint was the disease control rate (complete or partial response or stable disease) at 12 weeks. The null hypothesis was rejected if 11 patients or more had disease control.

Median follow-up was 18.4 weeks (interquartile range [IQR] = 6.7–23.9 weeks). Disease control was achieved at 12 weeks in 14 (54%, 95% confidence interval [CI] = 36%–71%) of 26 patients, with partial response in 3 (12%, 95% CI = 3%–27%) and stable disease in 11 (42%, 95% CI = 26%–60%). An additional patient exhibited partial response by week 24. In post hoc analysis, median progression-free survival was 128 days (95% CI = 105–252 days).

In post hoc analysis, loss of MTAP expression was identified in 11 (44%) of 25 evaluable patients. No patients with progressive disease as best response had MTAP loss. Median change in tumor volume after treatment was –18% (IQR= –17% to –26%) for MTAP-negative tumors vs 0% (IQR = –3% to 0%) for MTAP-positive tumors (P = .02).

[Article continues at original source]

 Asbestos & Mesothelioma Information

  Asbestos-Mesothelioma Case Evaluation
Free.  Confidential.  No Obligation

Filed Under: Mesothelioma

Find What You Want Here

Get Free Case Evaluation

We encourage you to submit an online Case Evaluation Form – it is confidential and there is no obligation.

Or call our toll-free number, 800-426-9535, to speak directly to attorney Tom Lamb about your possible case.

Feel Free To Contact Us

Quick Contact Form
 
Send an Email to Tom Lamb

(800) 426-9535

Main Navigation Menu

  • About Firm
  • Asbestos-Mesothelioma Cases
  • Benzene Disease Claims
  • Drug Injury Lawsuits
  • Breast Implant Cancer Cases
  • Case Evaluation Menu
  • Quick Contact Form
  • Frequently Asked Questions
  • Medical Records Charges
  • Collection of Articles
  • Sitemap

Lamb Law Office Newsletter

Lamb Law Office Newsletter provides periodic updates about some of the cases that we are working on for clients, as well as an information resource you might find helpful.

Subscribe using Form below.

Subscription Form

* indicates required

Our Other Websites

DrugInjuryLaw.com

DrugInjuryWatch.com

Asbestos-Mesothelioma.com

Contact Information

Law Offices of Thomas J. Lamb, P.A.
1908 Eastwood Road, Suite 225
Wilmington, North Carolina 28403
910-256-2971 | 800-426-9535
TJL@LambLawOffice.com

  • Home
  • Disclaimer and Copyright Notices
  • Sitemap

Copyright © 2025 · Law Offices of Thomas J. Lamb, P.A.