The following GenX study results were summarized from the reports of “substantial risk of injury to health or the environment” produced by DuPont and filed with the US Environmental Protection Agency (EPA) concerning GenX.
Subject animal(s): rats in 1963 study
Side effects:
○ Convulsive deaths
○ Enlarged livers
○ Degenerative changes in pancreas
Subject animal(s): rabbit and mice
Side effects:
○ Deaths
○ Eye damage
○ Dermal effects
○ Lethargy, cool to touch
○ Reduction of body weight
Subject animal(s): mice
Side effects:
○ Increased liver weight
Subject animal(s): rats
Side effects:
○ Increased kidney and liver weights
○ Hypertrophy of liver
○ Decreases in red blood cell mass parameters
Subject animal(s): daphnia magna (water fleas)
Side effects:
○ Deaths
○ Reproductive effects
Subject animal(s): rats (inhaled substance)
Side effects:
○ Body weight losses
○ Pathology effects
○ Respiratory effects
○ Death
Subject animal(s): rats
Side effects:
○ Deaths
○ Lesions on kidneys, stomach, bladder, and thymus
○ Heart and spinal cord issues
○ Increased kidney / liver weight
○ Hepatocellular hypertrophy
○ Decreased red blood cell mass
○ Anemia
Subject animal(s): mice
Side effects:
○ Increased kidney, liver, and adrenal weights
○ Liver hypertrophy
○ Pathology differences
Subject animal(s): mice
Side effects:
○ Early fetal delivery
○ Lower fetal weight
○ Increased kidney and liver weight
The test substance was not biodegradable.
Subject animal(s): northern bobwhite quail
Side effects:
○ Lesions on feet and head
○ Reduction in embryo viability
Subject animal(s): mice
Side effects:
○ Increase in body weights
○ Increased food consumption
○ Increased kidney and liver weight
○ Lower offspring weights
Subject animal(s): rats
Side effects:
○ Death
○ Increased kidney and liver weight
○ Lower fetal weight
○ Early fetal delivery
○ Hepatocellular hypertrophy
Subject animal(s): rainbow trout
Side effects:
○ Various effects on hatching, growth, and survival
Subject animal(s): mice
Side effects:
○ Increase in gross white areas in liver
○ Hepatocellular hypertrophy
○ Increased kidney and liver weights
○ Liver lesions
○ Lower plasma levels
Subject animal(s): rats
Side effects:
○ Tumors in pancreas, testes, and liver
○ Increased liver weight, degeneration, and necrosis
○ Adverse effects on kidney, stomach, and tongue
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