Introduction: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) is an accepted treatment for peritoneal mesothelioma. In this study, we evaluated [ quality of life (QOL) ] after [ hyperthermic intraperitoneal chemotherapy (HIPEC) ] for peritoneal mesothelioma.
Methods: This was a prospective study performed after [ hyperthermic intraperitoneal chemotherapy (HIPEC) ] for peritoneal mesothelioma between 2002 and 2015. Patients completed [ quality of life (QOL) ] surveys, including the Short Form-36 (SF-36), Functional Assessment of Cancer Therapy?+?Colon (FACT-C), Brief Pain Inventory (BPI), and Center for Epidemiologic Studies Depression Scale (CES-D) preoperatively and at 3, 6, 12, and 24 months postoperatively.
Results: Overall, 46 patients underwent [ hyperthermic intraperitoneal chemotherapy (HIPEC) ] for peritoneal mesothelioma and completed QOL surveys. Mean age was 52.8?±?13.8 years and 52% were male. Good preoperative functional status was 70%. Median survival was 3.4 years, and 1, 3, and 5-year survivals were 77.4, 55.2, and 36.5%, respectively. CES-D score decreased at 3 months postoperatively, but increased at 24 months (p?=?0.014); SF-36 physical functioning scale decreased at 3 months but returned to baseline at 12 months (p?=?0.0045); and the general health scale decreased at 3 months, then improved by 6 months (p?=?0.0034). Emotional well-being (p?=?0.0051), role limitations due to emotional problems (p?=?0.0006), social functioning (p?=?0.0022), BPI (p?=?0.025), least pain (p?=?0.045), and worst pain (p?<?0.0001) improved. FACT-C physical well-being decreased at 3 months but returned to baseline at 6 months (p?=?0.020), and total FACT-C score improved at 6 months (p?=?0.052).
Conclusion: [ Quality of life (QOL) ] returned to baseline or improved from baseline between 3 months and 1 year following surgery. Despite the risks associated with this operation, patients may tolerate [hyperthermic intraperitoneal chemotherapy (HIPEC)] well and have good overall [ quality of life (QOL) ] postoperatively.
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