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New Heartburn Drugs Study Shows 33% Increased Risk of Kidney Problems

November 8, 2017 By Law Offices of Thomas J. Lamb, P.A.


Previous Research on PPIs & Kidney Damage

Several studies have been published in the past several years concerning the relationship between chronic kidney disease (CKD) and proton pump inhibitors (PPIs) such as Nexium, Prilosec, and Prevacid.

The table below identifies the year, title, and results of three recent studies on PPIs and kidney problems such as acute interstitial nephritis (AIN), acute kidney injury (AKI), and CKD:

April 2015 “Proton pump inhibitors and the risk of acute kidney injury in older patients: a population-based cohort study”
  • 3x the increased risk of AIN
  • 2.5x the increased risk of AKI
January 2016 “Proton Pump Inhibitor Use and the Risk of Chronic Kidney Disease”
  • 35-50% increased risk of CKD
April 2016 “Proton Pump Inhibitors and Risk of Incident CKD and Progression to ESRD”
  • 28% increased risk of CKD (Compared to those taking H2 Blockers)

New Findings and Increased Risks

The results of a recent study titled, “Proton Pump Inhibitors and Risk of Chronic Kidney Diseases: A Meta-Analysis” were discussed at American Society of Nephrology (ASN) Kidney Week 2017.

While the actual study results have not yet been published, the press release from the ASN reports that those using PPIs had a 33% increased risk of developing CKD or kidney failure compared to those who did not take the drugs.

This new study was a meta-analysis of five previous studies, which included a total of 536,902 participants.

One of the leading researchers, Charat Thongprayoon, MD (Bassett Medical Center), stated the following:

This study demonstrates a significant association between the use of PPIs and increased risks of chronic kidney disease and kidney failure…Although no causal relationship has been proven, providers should consider whether PPI therapy is indicated for patients. Chronic use of PPIs should be avoided if not really indicated.

What This Means

While a 33% increased risk may not sound very significant to most users of Nexium, Prilosec, Prevacid, or other PPIs, it becomes more alarming when considering just how many people are using these drugs.

PPIs are one of the most commonly prescribed medications, with millions of users worldwide.

In addition to prescriptions, these drugs can be obtained over-the-counter.  As such, it is vital that the labels for these drugs contain information about the increased risk of CKD and other kidney problems identified in research.

We will continue to monitor the medical literature for additional study results and label changes, then report on significant developments.

 

 

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Previous articles on this topic:

  • Nexium / Prilosec / Prevacid: Valuing Profits Over Patients
  • Nexium / Prevacid / Prilosec Series: The Devastating Side Effects
  • Association Between Heartburn Drugs & Chronic Kidney Disease Questioned

Filed Under: Unsafe Drugs Tagged With: Acute Interstitial Nephritis, Acute Kidney Injury, ain, aki, chronic kidney disease, ckd, drug injury lawsuits, drug side effects, end stage renal disease, esrd, heartburn drugs, heartburn drugs side effects, Kidney Failure, Nexium, ppi drugs, Prevacid, Prilosec, proton pump inhibitors, Renal Failure, unsafe drugs

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