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Actemra Drug-Induced Liver Injuries Warning From Health Canada

May 29, 2019 By Law Offices of Thomas J. Lamb, P.A.

Actemra drug-induced liver injuries, which can be serious, life-threatening, or even fatal. This is according the Canadian drug regulatory agency, Health Canada, which issued this Dear Healthcare Professional Letter, “Important Safety Information on ACTEMRA ® (tocilizumab) – Risk of Hepatotoxicity”, on May 21, 2019.

From this Health Canada document we get the following:

Eight cases of ACTEMRA-related moderate to severe [drug-induced liver injury (DILI)] were identified. These events occurred between 2 weeks to more than 5 years after initiation of [Actemra (tocilizumab)] with median latency of 98 days. Two of these 8 cases required liver transplantation.

As background, Actemra is a prescription medicine used to treat:

  • adults with moderate to severe rheumatoid arthritis;
  • adults with giant cell arteritis, an inflammation in the arteries, especially the ones in the temples; and,
  • children older than 2 years with certain types of arthritis.

We will watch to see whether the FDA issues a similar drug safety warning about Actemra-related liver injury and mandates a drug label change here in the US.

[View article at original source]

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Filed Under: Uncategorized, Unsafe Drugs Tagged With: Actemra, drug-induced liver injury, liver damage, liver failure, liver transplants

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