Law Offices of Thomas J. Lamb

  • Asbestos & Mesothelioma
  • Benzene Diseases
  • Camp Lejeune Cases
  • Drug Injury
  • Free Case Evaluation
  • About Us

Association Between Heartburn Drugs & Chronic Kidney Disease Questioned

September 7, 2017 By Law Offices of Thomas J. Lamb, P.A.


A recent article published in The Journal of Allergy and Clinical Immunology titled The “dangers” of chronic proton pump inhibitor use provides commentary on the relationship between use of proton pump inhibitors (PPIs)–such as Nexium, Prilosec, and Prevacid–and various side effects.

The authors of this study acknowledge the growing number of serious side effects that are reported to be associated with PPI use, and seek to whittle down the list to only those with the strongest association.

They ranked the reported side effects in terms of “observed effects,” “hypothesized effects (not observed),” and “reported weak association.”

As regards side effects that are the subject injuries of current lawsuits against the responsible drug manufacturers, the researchers ranked them as follows:

  • Acute interstitial nephritis (AIN): observed effect
  • Chronic kidney disease (CKD): reported weak association

While this article states that there is a “weak” association between CKD and PPI use, other studies would disagree.

One study in particular, Long-term kidney outcomes among users of proton pump inhibitors without intervening acute kidney injury, published in February of this year, provides the following information:

Proton pump inhibitor (PPI) use is associated with an increased risk of acute kidney injury (AKI), incident chronic kidney disease (CKD), and progression to end-stage renal disease (ESRD). PPI-associated CKD is presumed to be mediated by intervening AKI.

The goal of the study was to find out whether PPI use is associated with an increased risk of chronic renal outcomes in the absence of intervening AKI.

Based on their findings, they concluded that:

PPI use is associated with increased risk of chronic renal outcomes in the absence of intervening AKI. Hence, reliance on antecedent AKI as warning sign to guard against the risk of CKD among PPI users is not sufficient as a sole mitigation strategy.

Additional studies also support the relationship between PPIs and chronic kidney disease, such as Proton Pump Inhibitor Use and the Risk of Chronic Kidney Disease and Popular heartburn drugs linked to gradual yet ‘silent’ kidney damage, both published in February of 2016.
We will continue to monitor the medical literature concerning the relationship between PPIs and various side effects such as CKD, AIN, ESRD, acute kidney injury, and kidney failure.
In the meantime, visit our website to learn more about these drugs and their possible side effects, and complete a free case evaluation if you or someone you know have regularly used PPIs and been diagnosed with one of the aforementioned conditions.

Written by: Heather Helmendach, Legal Assistant
Law Offices of Thomas J. Lamb, P.A.


Drug Injury Watch
: Side Effects News & Reports

Drug Injury Law: Medical & Legal Information

Filed Under: Unsafe Drugs Tagged With: Acute Interstitial Nephritis, Acute Kidney Injury, ain, aki, chronic kidney disease, ckd, drug injury lawsuits, drug side effects, end stage renal disease, esrd, heartburn drugs, heartburn drugs side effects, Kidney Failure, Nexium, ppi drugs, Prevacid, Prilosec, proton pump inhibitors, Renal Failure, unsafe drugs

Find What You Want Here

Get Free Case Evaluation

We encourage you to submit an online Case Evaluation Form – it is confidential and there is no obligation.

Or call our toll-free number, 800-426-9535, to speak directly to attorney Tom Lamb about your possible case.

Feel Free To Contact Us

Quick Contact Form
 
Send an Email to Tom Lamb

(800) 426-9535

Main Navigation Menu

  • About Our Firm
  • Asbestos-Mesothelioma Cases
  • Benzene Disease Claims
  • PFAS Firefighter Gear Lawsuits
  • Camp Lejeune Cases
  • GenX Water Cancer Cases
  • Drug Injury Lawsuits
  • Breast Implant Cancer Cases
  • Philips Breathing Devices Cases
  • Case Evaluation Menu
  • Quick Contact Form
  • Frequently Asked Questions
  • Medical Records Charges
  • Collection of Articles
  • Sitemap

Lamb Law Office Newsletter

Lamb Law Office Newsletter provides periodic updates about some of the cases that we are working on for clients, as well as an information resource you might find helpful.

Subscribe using Form below.

Subscription Form

* indicates required

Our Other Websites

Drug Injury Law
Drug Injury Watch
Drug Safety Developments
Asbestos & Mesothelioma

Contact Information

Law Offices of Thomas J. Lamb, P.A.
1908 Eastwood Road, Suite 225
Wilmington, North Carolina 28403
910-256-2971 | 800-426-9535
TJL@LambLawOffice.com

  • Home
  • Frequently Asked Questions
  • Disclaimer and Copyright Notices

Copyright © 2023 · Law Offices of Thomas J. Lamb, P.A.